This book brings together two research and policy agendas to advance an interdisciplinary social-ecological approach to environmental sustainability putting health and fairness at the center of the understanding of both ecological interdependence and social cooperation.The first agenda, that has been around for at least five decades, focuses on the need to go beyond Gross Domestic Product (GDP) and economic growth in order to imagine new social horizons that put sustainable human well-being at the heart of economic and social policies in order to stop the irrational destruction of the Biosphere. The second agenda, relatively more recent, centers on articulating social issues and environmental challenges to overcome damaging but also illusory trade-offs such as "the economy vs. the environment". While these agendas are gaining momentum, they do so in isolation. Bringing them together to outline a social-ecological transition beyond growth entails at least three tasks: showing how current environmental, economic and social crises are intertwined in the beginning of the 21st century; imagining new narratives and analytical frameworks linking social and natural systems; designing policies and institutions to sustain the social-ecological transition beyond 20th century economic models. This book aims at advancing these three agendas.