Glutamate/GABA-Glutamine Cycle

Name: Glutamate/GABA-Glutamine Cycle
Brand: Springer International Publishing AG
SKU: 9783319450940
Price: 842.1 PLN
Availability: InStock

Amino Acid Neurotransmitter Homeostasis

Autor: Arne Schousboe, Ursula Sonnewald

Język:

Oprawa: Twarda

Wydawca: Springer International Publishing AG

Dostępność: Dostępna u dostawcy

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Fundamental biochemical studies of basic brain metabolism focusing on the neuroactive amino acids gl...

Informacje o książce

Autor

Arne Schousboe, Ursula Sonnewald

Język

Angielski

Oprawa

Książka - Twarda

Data wydania

2016

strony

416

EAN

9783319450940

ISBN

3319450948

Enbook ID

13633873

Wydawca

Springer International Publishing AG

Waga

7627

Wymiary

155 x 235 x 30

Pełny opis

Fundamental biochemical studies of basic brain metabolism focusing on the neuroactive amino acids glutamate and GABA combined with the seminal observation that one of the key enzymes, glutamine synthetase is localized in astroglial cells but not in neurons resulted in the formulation of the term "The Glutamate-Glutamine Cycle". In this cycle glutamate released from neurons is taken up by surrounding astrocytes, amidated by the action of glutamine synthetase to glutamine which can be transferred back to the neurons. The conversion of glutamate to glutamine is like a stealth technology, hiding the glutamate molecule which would be highly toxic to neurons due to its excitotoxic action. This series of reactions require the concerted and precise interaction of a number of enzymes and plasma membrane transporters, and this volume provides in-depth descriptions of these processes. Obviously such a series of complicated reactions may well be prone to malfunction and therefore neurological diseases are likely to be associated with such malfunction of the enzymes and transporters involved in the cycle. These aspects are also discussed in several chapters of the book.§ A number of leading experts in neuroscience including intermediary metabolism, enzymology and transporter physiology have contributed to this book which provides comprehensive discussions of these different aspects of the functional importance of the glutamate-glutamine cycle coupling homeostasis of glutamatergic, excitatory neurotransmission to basic aspects of brain energy metabolism. This book will be of particular importance for students as well as professionals interested in these fundamental processes involved in brain function and dysfunction. §

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Glutamate/GABA-Glutamine Cycle

Amino Acid Neurotransmitter Homeostasis

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