Methods in Membrane Biology

Name: Methods in Membrane Biology
Brand: Springer-Verlag New York Inc.
SKU: 9781468409871
Price: 245.08 PLN
Availability: InStock

Volume 10

Autor: Edward D. Korn

Język:

Oprawa: Miękka

Wydawca: Springer-Verlag New York Inc.

Dostępność: Dostępna u dostawcy w małych ilościach

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Three articles make up Volume 10 of Methods in Membrane Biology. In the first of these, Papahadjopou...

Informacje o książce

Autor

Edward D. Korn

Język

Angielski

Oprawa

Książka - Miękka

Data wydania

2012

strony

227

EAN

9781468409871

ISBN

1468409875

Enbook ID

05181752

Wydawca

Springer-Verlag New York Inc.

Waga

362

Wymiary

152 x 229 x 14

Pełny opis

Three articles make up Volume 10 of Methods in Membrane Biology. In the first of these, Papahadjopoulos, Poste, and Vail extensively review much of the available data on the fusion of natural membranes, model membranes (liposomes), and natural membranes with liposomes. The authors are led by their review of the experimental methods and their interpretations of the results obtained to a general theory of membrane fusion which they believe is applicable to all systems that have been studied. Arguing that although protein and carbohydrate may serve, in some cases, to bring membranes into sufficiently close proximity for fusion to occur and, in other cases, to remove peripheral and integral proteins from the regions that are to undergo fusion, the authors conclude that membrane fusion per se is solely a property of the lipid bilayer. In their view, all the experimental observations to date can be subsumed under a unifying hypothesis in which membrane fusion is the result of a phase separation in one-half of the membrane bilayer brought about by the interaction - of calcium ions with acidic phospholipids, mostly phosphatidylserine. Where half-membranes already contain sufficient acidic phospholipids, a local increase in calcium ion concentration may suffice to induce fusion (examples might include exocytosis and fusion of intracellular membrane systems). In other cases, natural or experimentally induced events preceding fusion might be necessary to increase the local concentration of the acidic phospholipids in the half-membrane (virus-or fusogenic agent-induced cell-to-cell fusion, or endocytosis, for example).

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Methods in Membrane Biology

Volume 10

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