Książka Histone Recognition Ming-Ming Zhou

Histone Recognition

Język: Angielski
Oprawa: Twarda
Dostępność: Dostępna u dostawcy
Wysyłamy za 10-13 dni
424.83
This book provides a timely review of the role of histone modifications in epigenetic control of gen...

Informacje o książce

Język
Angielski
Oprawa
Książka - Twarda
Data wydania
2015
strony
282
EAN
9783319181011
ISBN
3319181017
Enbook ID
09255758
Waga
720
Wymiary
155 x 235 x 243

Pełny opis

This book provides a timely review of the role of histone modifications in epigenetic control of gene expression. Topics covered include: basic mechanisms of molecular recognition of histone post-translational modification (PTMs); combinatorial readout of histone PTMs by tandem epigenome reader domains; genome-wide profiling of histone PTM interactions; small molecule modulation of histone PTM interactions and their potential as a new approach to therapeutic intervention in human diseases. All chapters were written by leading scientists who made the original key discoveries of the structure and mechanism of evolutionarily conserved reader domains, which serve to direct gene transcription in chromatin through interactions with DNA-packing histones in a PTM-sensitive manner.§

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