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Tumor Suppressor Par-4

Name: Tumor Suppressor Par-4
Brand: Springer Nature Switzerland AG
SKU: 9783030735715
Price: 728.93 PLN
Availability: InStock

Structural Features, Molecular Mechanisms and Function

Autor: Vivek M. Rangnekar

Język:

Oprawa: Twarda

Wydawca: Springer Nature Switzerland AG

Dostępność: Dostępna u dostawcy

Wysyłamy za 10-13 dni

728.93 zł

Par-4 is a tumor suppressor protein first discovered and identified in 1993 by Dr. Vivek Rangnekar's...

Informacje o książce

Autor

Vivek M. Rangnekar

Język

Angielski

Oprawa

Książka - Twarda

Data wydania

2022

strony

323

EAN

9783030735715

ISBN

3030735710

Enbook ID

37628728

Wydawca

Springer Nature Switzerland AG

Waga

670

Wymiary

155 x 235 x 24

Pełny opis

Par-4 is a tumor suppressor protein first discovered and identified in 1993 by Dr. Vivek Rangnekar's laboratory in prostate cancer cells undergoing apoptosis. Par-4 (later also known as PAWR) is a naturally occurring tumor suppressor. Studies have indicated that Par-4 selectively induces apoptosis in cancer cells while leaving normal, healthy, cells unaffected. Mechanisms contributing to the cancer-selective action of Par-4 have been associated with protein kinase A activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. Par-4 is downregulated, inactivated or mutated in diverse cancers. This first of two volumes will be the first on the market on the topic of Par-4, and will provide the opportunity for researchers to discuss the future direction of studies, broaden the scope of research, and contribute a more complete understanding of the molecule's structural features, key functional domains, regulation and relevant basic and clinical/translational facets.