Tubulin-Binding Agents

Name: Tubulin-Binding Agents
Brand: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
SKU: 9783540690368
Price: 1424.98 PLN
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Synthetic, Structural and Mechanistic Insights

Autor: Teresa Carlomagno

Język:

Oprawa: Twarda

Wydawca: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG

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reviews. The SAR data are discussed in light of the structural information available for each agent....

Informacje o książce

Autor

Teresa Carlomagno

Język

Angielski

Oprawa

Książka - Twarda

Data wydania

2009

strony

331

EAN

9783540690368

ISBN

3540690360

Enbook ID

01567816

Wydawca

Springer-Verlag Berlin and Heidelberg GmbH & Co. KG

Waga

673

Wymiary

155 x 235 x 27

Pełny opis

reviews. The SAR data are discussed in light of the structural information available for each agent. The second chapter focuses on the total synthesis of the marine sponge-derived polyketide discodermolide. A comprehensive survey of the synthetic chemistry efforts of several groups over a 14-year period is provided together with a compa- son of the different approaches. The third chapter describes a comprehensive study of the mechanisms of activity of microtubules stabilizing drugs. Thermodynamic, kinetic, structural and fu- tional data on microtubules stabilizing drugs are discussed in an interdisciplinary manner to generate a time-resolved picture of the interaction of the drugs with different tubulin forms. The fourth and fifth chapters review the efforts and achievements made in the characterization of the structure of the complexes of tubulin with microtubules stabilizing agents by NMR (Chapter 4) and EM (Chapter 5). Especially evident is the discrepancy of the results obtained for epothilones, where the two techniques deliver radically different structures of the bound drug. Both NMR and EM models are, however, able to explain a consistent set of SAR data. The authors of the two chapters discuss critically the advantages and limitations of each methodology.

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Tubulin-Binding Agents

Synthetic, Structural and Mechanistic Insights

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