The Fluoroquinolone Connection

Name: The Fluoroquinolone Connection
Brand: LAP Lambert Academic Publishing
SKU: 9783330063693
Price: 90.22 PLN
Availability: InStock

Dissimilar Fitness Associated with Resistance to Fluoroquinolones Influences Clonal Dynamics of Multiresistant Bacteria

Autor: Miklos Fuzi

Język:

Oprawa: Miękka

Wydawca: LAP Lambert Academic Publishing

Dostępność: Dostępna u dostawcy

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Author falling back on findings published by his group and reviewing data reported by other scientis...

Informacje o książce

Autor

Miklos Fuzi

Język

Angielski

Oprawa

Książka - Miękka

Data wydania

2017

strony

EAN

9783330063693

Enbook ID

16123200

Wydawca

LAP Lambert Academic Publishing

Waga

Wymiary

150 x 220 x 3

Pełny opis

Author falling back on findings published by his group and reviewing data reported by other scientists shows how the extensive use of fluoroquinolones influenced the evolution of various multiresistant pathogens on a global scale. It is demonstrated that most bacteria will suffer enormous fitness costs when developing high-level resistance to fluoroquinolones. However, a few "skillful" groups of pathogens proved capable of evolving favorable mutations conferring high-level resistance to fluoroquinolones with the concomitant preservation of vitality. As these multiresistant "superbugs" have replaced other pathogens in many facilities they also contributed to the deterioration of the general antibiotic resistance status. Though further epidemiological studies are needed the available data strongly suggest that the judicious use of fluoroquinolones could be based on the constant monitoring of the clonal division of local pathogens: if the proportion of "superbugs" is high a reduction in the use of fluoroquinolones should ameliorate the situation, however, when their proportion remains/becomes low the use of fluoroquinolones should be highly beneficial.

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The Fluoroquinolone Connection

Dissimilar Fitness Associated with Resistance to Fluoroquinolones Influences Clonal Dynamics of Multiresistant Bacteria

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