Structure-function study and engineering of eubacterial flagellin

Name: Structure-function study and engineering of eubacterial flagellin
Brand: VDM Verlag Dr. Müller
SKU: 9783639171143
Price: 329.51 PLN
Availability: InStock

Eubacterial flagellin engineering

Autor: Venkata R. Malapaka

Język:

Oprawa: Miękka

Wydawca: VDM Verlag Dr. Müller

Dostępność: Na zamówienie

Wysyłamy za 17-27 dni

329.51 zł

In the past few decades biology has been revolutionized by the advances in molecular biology and gen...

Informacje o książce

Autor

Venkata R. Malapaka

Język

Angielski

Oprawa

Książka - Miękka

Data wydania

2009

strony

284

EAN

9783639171143

Enbook ID

06825451

Wydawca

VDM Verlag Dr. Müller

Waga

439

Wymiary

150 x 220 x 17

Pełny opis

In the past few decades biology has been revolutionized by the advances in molecular biology and genetic engineering. Bacterial systems have been in the forefront of this revolution and our understanding of life has been extended by their genetic manipulation. This work explores the feasibility of engineering the flagellin protein of Salmonella typhimurium to display proteins/peptides and create bio-nanotubes. Flagellin protein that forms the fiber is the major component of bacterial flagellar system. Due to its abundance and export to the cell surface it forms an ideal platform for displaying desired proteins/ peptides. The central domain of the protein that is exposed to the periphery of the fiber is highly variable and can be deleted to a large extent. This makes it possible to insert different proteins and peptides in the middle domain and display them on surface of the fiber. Such system can have important applications in the display of commercially important proteins/peptides, antibody epitopes and bio-degrading enzymes. The current work also explores the protein structure of hyperthermostable flagellin that can serve as a thermostable display system.

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Structure-function study and engineering of eubacterial flagellin

Eubacterial flagellin engineering

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