Książka Statistical Methods for CGH Array Analysis Pei Wang

Statistical Methods for CGH Array Analysis

Autor: Pei Wang
Język: Angielski
Oprawa: Miękka
Wydawca: VDM Verlag
Dostępność: Na zamówienie
Wysyłamy za 17-27 dni
205.23
Genomic DNA copy number alterations are key genetic events in the initiation and progression of huma...

Informacje o książce

Autor
Język
Angielski
Oprawa
Książka - Miękka
Data wydania
2010
strony
38
EAN
9783639114065
ISBN
363911406X
Enbook ID
06820282
Wydawca
Waga
68
Wymiary
152 x 229 x 2

Pełny opis

Genomic DNA copy number alterations are key genetic events in the initiation and progression of human cancers. Recent advance in the technique of microarray comparative genomic hybridization (array CGH) enables one to screen genome-wide for all possible regions with DNA copy number alterations, such as chromosome gains and losses, or localized amplifications and deletions. In this book, we introduce two statistical methods addressing two different questions for the data analysis of array CGH. The first method---Cluster Along Chromosomes--- is developed for calling gains and losses in CGH arrays. The second method--- Boosted PRIM (Patient Rule Induction Method)--- is developed to search for oncogenic pathways using array-CGH data. The performance of the methods are illustrated through both simulation studies and real applications.

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