Książka Selective Estrogen Receptor Modulators Andrea Manni

Selective Estrogen Receptor Modulators

Research and Clinical Applications

Język: Angielski
Oprawa: Miękka
Dostępność: Dostępna u dostawcy w małych ilościach
Wysyłamy za 13-18 dni
513.03
Experimental and clinical researchers from a wide range of disciplines present a wealth of fresh sci...

Informacje o książce

Język
Angielski
Oprawa
Książka - Miękka
Data wydania
2012
strony
374
EAN
9781468496659
ISBN
1468496654
Enbook ID
02643780
Waga
728
Wymiary
178 x 254 x 21

Pełny opis

Experimental and clinical researchers from a wide range of disciplines present a wealth of fresh scientific information on the biochemistry, molecular biology, pharmacology, and clinical activity of SERMs. The basic science chapters of the book focus-with an eye to the development of the ideal SERM-on the complex mechanisms of estrogen action, including ligand-dependent conformational changes in alpha and beta, and the recruitment of co-activators and co-repressors which modulate the estrogen receptor transcriptional activity and contribute to its crosstalk with growth factor signaling. The clinical presentation reviews the data accumulated on currently available SERMs, primarily tamoxifen and raloxifene, in cancer treatment and prevention, as well as their effects on the reproductive, vascular, skeletal, and central nervous systems. A tentative approach to menopause-related health issues is also provided for women with and without a previous diagnosis of localized breast cancer.

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