Protein Structure Prediction and Molecular Dynamics Simulation

Name: Protein Structure Prediction and Molecular Dynamics Simulation
Brand: VDM Verlag
SKU: 9783639300277
Price: 255.66 PLN
Availability: InStock

Structure Prediction of Wild-Type Human MTHFR, Comparison with Mutants and MD Simulation of the Final Model

Autor: Khuram Shahzad, Asifa Ahmed, Zaheer Ul Haq

Język:

Oprawa: Miękka

Wydawca: VDM Verlag

Dostępność: Dostępna u dostawcy

Wysyłamy za 9-15 dni

255.66 zł

Structure Prediction is one of the most important aspects of Structural Bioinformatics, Protein Dock...

Informacje o książce

Autor

Khuram Shahzad, Asifa Ahmed, Zaheer Ul Haq

Język

Angielski

Oprawa

Książka - Miękka

Data wydania

2010

strony

148

EAN

9783639300277

ISBN

3639300270

Enbook ID

06837037

Wydawca

VDM Verlag

Waga

227

Wymiary

152 x 229 x 9

Pełny opis

Structure Prediction is one of the most important aspects of Structural Bioinformatics, Protein Docking and Drug Designing. The current study is performed on MTHFR enzyme. It plays an important role in folate and homocysteine metabolism by catalyzing the conversion of 5,10-methylenetetrahydrofolate to 5- methyltetrahydrofolate, used for homocysteine remethylation to methionine. MTHFR mutations have been found in a large number of diseases. However, the structure of MTHFR is still unknown, thereby limiting the understanding of structure function relationship to the diseased state. Different Bioinformatics methodologies were used to predict and compare the 3D structure of the wild-type and its mutants. The predicted models were visualized by VMD, RasMol and Pymol. Evaluation of the predicted models was performed using DFIRE, Verify3D, ANOLEA and PROCHECK. Selected Model was compared with its mutants and then simulated. MTHFR mutants were seen to have decreased number of serine phosphorylation sites as compared to wild-type. Phosphorylation seems to be playing a significant role in function of this enzyme.

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Protein Structure Prediction and Molecular Dynamics Simulation

Structure Prediction of Wild-Type Human MTHFR, Comparison with Mutants and MD Simulation of the Final Model

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Pełny opis

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