Książka Protein-Protein Interactions (PPIs) Clyde R Montgomery

Protein-Protein Interactions (PPIs)

Types, Methods for Detection Analysis

Język: Angielski
Oprawa: Miękka
Dostępność: 50 % szansa
Przeszukamy cały świat
605.62
Protein-protein interactions (PPIs) play an important role in vital biological processes such as met...

Informacje o książce

Język
Angielski
Oprawa
Książka - Miękka
Data wydania
2016
strony
130
EAN
9781634859707
ISBN
1634859707
Enbook ID
14263174
Waga
368
Wymiary
157 x 234 x 15

Pełny opis

Protein-protein interactions (PPIs) play an important role in vital biological processes such as metabolic and signaling pathways, cell cycle control, and DNA replication and transcription. This book discusses types, methods for detection and the analysis of PPIs. Chapter One describes two key nuclear magnetic resonance (NMR) methods for the investigation of protein-protein interactions, chemical shift perturbation, and residual dipolar coupling, with practical tips on the preparation of samples, NMR measurement, and analysis. Chapter Two describes the basic principles and provides a practical description of the recent technological developments in solution NMR spectroscopy for examining protein-protein interactions. Chapter Three focuses on identifying PPIs via many learning methods based on protein sequence information. Chapter Four examines the thermodynamics of PPIs by isothermal titration calorimetry. Chapter Five describes the general microscopic features of amyloid fibril structures and then discusses the macroscopic properties of protein aggregate with conformations such as packing, hydration, and enthalpy using thermodynamic variables in combination with densitometry and isothermal titration calorimetry. Chapter Six reviews the special case of protein self-association as a modulator of protein function.

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