Angielski
New Opioid Receptor Modulators and Agonists: Relevance for Pain and Opioid Use Disorder Management is indispensable for anyone interested in development of an ideal synthetic opioid. It offers a thorough discussion of the structures and mechanisms of opioid receptor modulators’ actions, and the potential applications of these molecules in the treatment of pain, opioid misuse, and addiction. It encompasses current research and therapeutic development avenues with respect to the structure and function of opioid receptors. Readers will gain a comprehensive understanding of the development of an ideal synthetic opioid, as well as the potential for future research and development. New Opioid Receptor Modulators and Agonists: Relevance for Pain and Opioid Use Disorder Management provides a comprehensive overview of the opioid receptor system and novel aspects of opioid pharmacology. It covers the rationale and potential of the development of allosteric modulators for opioid receptors, identification of potential allosteric sites on opioid receptors, and modes of action of the modulators. It also discusses pharmacogenomics and precision medicine as they relate to opioid-related interactions and metabolism considerations, and various syndromes and comorbidities associated with opioid use. Finally, it reviews categories of novel synthetic opioids and the associated risks of misuse and overdose.
