Mitochondrial Oxidative Phosphorylation

Name: Mitochondrial Oxidative Phosphorylation
Brand: Springer-Verlag New York Inc.
SKU: 9781461435723
Price: 849.15 PLN
Availability: InStock

Nuclear-Encoded Genes, Enzyme Regulation, and Pathophysiology

Autor: Bernhard Kadenbach

Język:

Oprawa: Twarda

Wydawca: Springer-Verlag New York Inc.

Dostępność: Dostępna u dostawcy

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This book will describe the nuclear encoded genes and their expressed proteins of mitochondrial oxid...

Informacje o książce

Autor

Bernhard Kadenbach

Język

Angielski

Oprawa

Książka - Twarda

Data wydania

2012

strony

372

EAN

9781461435723

ISBN

1461435722

Enbook ID

01427802

Wydawca

Springer-Verlag New York Inc.

Waga

736

Wymiary

240 x 161 x 26

Pełny opis

This book will describe the nuclear encoded genes and their expressed proteins of mitochondrial oxidative phosphorylation. Most of these genes occur in eukaryotic cells, but not in bacteria or archaea. The main function of mitochondria, the synthesis of ATP, is performed at subunits of proton pumps (complexes I, III, IV and V), which are encoded on mitochondrial DNA. The nuclear encoded subunits have mostly a regulatory function. However, the specific physiological functions of the nuclear encoded subunits of complexes I, III, IV, and V are mostly unknown. New data indicates that they are essential for life of higher organisms, which is characterized by an adult life without cell division (postmeiotic stage) in most tissues, after the juvenile growth. For complex IV (cytochrome c oxidase) some of these subunits occur in tissue-specific (subunits IV, VIa, VIb, VIIa, VIII), developmental-specific (subunits IV, VIa, and VIIa) as well as species-specific isoforms. Defective genes of some subunits were shown to induce mitochondrial diseases. Mitochondrial genes and human diseases will also be covered.

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Mitochondrial Oxidative Phosphorylation

Nuclear-Encoded Genes, Enzyme Regulation, and Pathophysiology

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