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Książka Novartis Foundation Symposium 287 - Mitochondrial Biology - New Perspectives Derek J. Chadwick

Novartis Foundation Symposium 287 - Mitochondrial Biology - New Perspectives

Autor: Derek J. Chadwick
Język: Angielski
Oprawa: Twarda
Wydawca: John Wiley & Sons Inc
Dostępność: Dostępna u dostawcy w małych ilościach
Wysyłamy za 11-15 dni
867.28 zł
With the recent renaissance in mitochondrial biology and increasing recognition of their role in man...

Informacje o książce

Autor
Derek J. Chadwick
Język
Angielski
Oprawa
Książka - Twarda
Data wydania
2007
strony
254
EAN
9780470066577
ISBN
0470066571
Enbook ID
04879401
Wydawca
John Wiley & Sons Inc
Waga
536
Wymiary
163 x 237 x 17

Pełny opis

With the recent renaissance in mitochondrial biology and increasing recognition of their role in many diseases, this book provides a timely summary of the current state-of-the-art in mitochondrial research. The book opens with the regulation of mitochondrial replication and biogenesis and reviews the mechanisms and functional consequences of mitochondrial fission and fusion. Further chapters address mitochondria and oxidative stress and their roles in cell signalling and cell death. The book includes extensive, fascinating discussion of the biochemistry of mitochondrial cell signalling (especially involving calcium) and of oxidative stress. The nature of the proteins engaged in these processes, many only recently discovered, is covered in detail. Mitochondria have been strongly implicated in neurodegenerative diseases such as Parkinson's, Huntington's and amyotrophic lateral sclerosis. They are also affected in cancer, ageing and cardiovascular disease. The final section of the book reviews mitochondrial mutations and their consequences in ageing and other phenotypic manifestations. The authors discuss how mitochondrial proteins might constitute important therapeutic targets and describe initial attempts to develop compounds that can regulate their function.

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