This book constitutes the§thoroughly refereed post-conference proceedings of the 6th International§Conference on Mathematical Aspects of Computer and Information Sciences, MACIS§2015, held in Berlin, Germany, in November 2015.§§The 48 revised papers presented§together with 7 invited papers were carefully reviewed and selected from§numerous submissions. The papers are grouped in topical sections on curves and§surfaces, applied algebraic geometry, cryptography, verified numerical§computation, polynomial system solving, managing massive data, computational§theory of differential and difference equations, data and knowledge exploration,§algorithm engineering in geometric computing, real complexity: theory and§practice, global optimization, and general session.§