Fullerene Derivatives

Name: Fullerene Derivatives
Brand: VDM Verlag Dr. Müller
SKU: 9783639005400
Price: 210.58 PLN
Availability: InStock

And Their Application in Bioanalytics

Autor: Rainer Vallant

Język:

Oprawa: Miękka

Wydawca: VDM Verlag Dr. Müller

Dostępność: Na zamówienie

Wysyłamy za 17-27 dni

210.58 zł

Fullerene derivatives, such as dioctadecyl methano fullerene, fullerenoacetic acid, and IDA-[60]-ful...

Informacje o książce

Autor

Rainer Vallant

Język

Angielski

Oprawa

Książka - Miękka

Data wydania

2008

strony

EAN

9783639005400

Enbook ID

06810674

Wydawca

VDM Verlag Dr. Müller

Waga

142

Wymiary

150 x 220 x 5

Pełny opis

Fullerene derivatives, such as dioctadecyl methano fullerene, fullerenoacetic acid, and IDA-[60]-fullerene were prepared and subjected to a comprehensive characterization study including protein binding properties and capacity. These fullerene derivatives were successfully applied as material-enhanced laser desorption/ionization (MELDI) carrier materials. It is shown that diverse functionalities result in characteristic human serum peak patterns (m/z 2000-20 000) which vary in terms of signal intensity as well as number of detectable masses. In addition, the fullerene derivatives clearly provided differences in the low molecular weight mass region (m/z 1000-4000) after elution of the adsorbed serum constituents. Monolithic, high-resolution capillary columns, were employed for eluate separation and target spotting. Thus, serum compounds were successfully fractionated and subjected to MS/MS analysis. This contribution, hence, proposes a new 'top-down' strategy for proteome research enabling protein profiling as well as biomarker identification in the low-mass range using selective enrichment, high-resolution separation, and offline MALDI-MS/MS evaluation.

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Fullerene Derivatives

And Their Application in Bioanalytics

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