Epitope Specificity & Polyfunctional CD4+ Responses In Majengo cohort

Name: Epitope Specificity & Polyfunctional CD4+ Responses In Majengo cohort
Brand: LAP Lambert Academic Publishing
SKU: 9783330032590
Price: 209.63 PLN
Availability: InStock

Autor: Marion Kiguoya-Njau

Język:

Oprawa: Miękka

Wydawca: LAP Lambert Academic Publishing

Dostępność: Dostępna u dostawcy

Wysyłamy za 5-8 dni

209.63 zł

A long standing study of low social economic status commercial sex workers, in the Majengo cohort of...

Informacje o książce

Autor

Marion Kiguoya-Njau

Język

Angielski

Oprawa

Książka - Miękka

Data wydania

2017

strony

132

EAN

9783330032590

Enbook ID

15823070

Wydawca

LAP Lambert Academic Publishing

Waga

215

Wymiary

150 x 220 x 8

Pełny opis

A long standing study of low social economic status commercial sex workers, in the Majengo cohort of Nairobi has demonstrated variable susceptibility to HIV-1, where some of the highly exposed subjects remain persistently seronegative, indicative of resistance to HIV -1. There has been intense interest in understanding the mechanism responsible for this phenomenon.This study evaluated the protective immunity in light of polyfunctional immune responses due to specific selective peptide recognition by in vitro stimulation of the subjects. The immune responses were measured. The Peripheral Blood Mononuclear Cells were obtained, stimulated and the responses measured for pro-inflammatory cytokines production at day three and for proliferation at day six of incubation at 37oC and 5% CO2. The resistant group showed significant levels of IFNGamma, TNF - , IL-2 production and proliferation, especially in response peptide pools 1, 12, 13 and 14 (Env, P24, P31 and P2P7P1, P6 P7, Protease and REV peptide pools).Future directions include breaking down the specific peptide pools with unique responses confirming polyfuctionality due to epitope specificity.

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Epitope Specificity & Polyfunctional CD4+ Responses In Majengo cohort

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