DNA Replicons - Next-generation Vaccines against Allergy

Name: DNA Replicons - Next-generation Vaccines against Allergy
Brand: VDM Verlag Dr. Mueller E.K.
SKU: 9783836495554
Price: 253.29 PLN
Availability: InStock

Autor: Maximilian Gabler

Język:

Oprawa: Miękka

Wydawca: VDM Verlag Dr. Mueller E.K.

Dostępność: Dostępna u dostawcy

Wysyłamy za 9-15 dni

253.29 zł

In this study, DNA vaccines based on alphaviral replicases (DNA replicons) were evaluated with respe...

Informacje o książce

Autor

Maximilian Gabler

Język

Angielski

Oprawa

Książka - Miękka

Data wydania

2008

strony

132

EAN

9783836495554

ISBN

3836495554

Enbook ID

06943333

Wydawca

VDM Verlag Dr. Mueller E.K.

Waga

186

Wymiary

152 x 229 x 7

Pełny opis

In this study, DNA vaccines based on alphaviral replicases (DNA replicons) were evaluated with respect to their protective and therapeutic capacity for treatment of type I allergy. DNA replicons display specific danger signals and offer an excellent safety profile based on apoptotic elimination of transfected host cells thereby preventing undesirable long-term expression of the transfected gene. Using the model allergen beta-Galactosidase in a protective approach, the results showed that a replicase-based DNA vaccine can induce a comparable immune response at a more than 1000-fold lower dose than a conventional DNA vaccine. DNA replicon doses as low as 10 ng significantly prevented from IgE induction by subcutaneous protein sensitization. Furthermore, in a therapeutic approach with the same construct, DNA replicons balanced an ongoing allergic response. These data were confirmed with a DNA replicon encoding the clinically relevant timothy grass pollen allergen Phl p 5. In addition, lung pathology could be prevented by pre-vaccination with DNA replicons as measured by the magnitude of eosinophilia, goblet cell hyperplasia, IL-5 production and proliferation of endothelial cells.

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