DNA Replication

Name: DNA Replication
Brand: Springer Verlag, Singapore
SKU: 9789811349720
Price: 696.96 PLN
Availability: InStock

From Old Principles to New Discoveries

Autor: Hisao Masai, Marco Foiani

Język:

Oprawa: Miękka

Wydawca: Springer Verlag, Singapore

Dostępność: Dostępna u dostawcy

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This book reviews the latest trends and future directions of DNA replication research. The contents...

Informacje o książce

Autor

Hisao Masai, Marco Foiani

Język

Angielski

Oprawa

Książka - Miękka

Data wydania

2018

strony

581

EAN

9789811349720

ISBN

9789811349720

Enbook ID

21993067

Wydawca

Springer Verlag, Singapore

Waga

1210

Wymiary

155 x 235 x 30

Pełny opis

This book reviews the latest trends and future directions of DNA replication research. The contents reflect upon the principles that have been established through the genetic and enzymatic studies of bacterial, viral, and cellular replication during the past decades. The book begins with a historical overview of the studies on eukaryotic DNA replication by Professor Thomas Kelly, a pioneer of the field. The following chapters include genome-wide studies of replication origins and initiation factor binding, as well as the timing of DNA replications, mechanisms of initiation, DNA chain elongation and termination of DNA replication, the structural basis of functions of protein complexes responsible for execution of DNA replication, cell cycle-dependent regulation of DNA replication, the nature of replication stress and cells' strategy to deal with the stress, and finally how all these phenomena are interconnected to genome instability and development of various diseases. By reviewing the existing concepts ranging from the old principles to the newest ideas, the book gives readers an opportunity to learn how the classical replication principles are now being modified and new concepts are being generated to explain how genome DNA replication is achieved with such high adaptability and plasticity. With the development of new methods including cryoelectron microscopy analyses of huge protein complexes, single molecular analyses of initiation and elongation of DNA replication, and total reconstitution of eukaryotic DNA replication with purified factors, the field is enjoying one of its most exciting moments, and this highly timely book conveys that excitement to all interested readers.

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DNA Replication

From Old Principles to New Discoveries

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