Copper-Catalyzed Multi-Component Reactions

Name: Copper-Catalyzed Multi-Component Reactions
Brand: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
SKU: 9783642154720
Price: 241.03 PLN
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Synthesis of Nitrogen-Containing Polycyclic Compounds

Autor: Yusuke Ohta

Język:

Oprawa: Twarda

Wydawca: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG

Dostępność: Dostępna u dostawcy w małych ilościach

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A copper-catalyzed direct synthesis of 2-(aminomethyl)indoles by catalytic domino reaction including...

Informacje o książce

Autor

Yusuke Ohta

Język

Angielski

Oprawa

Książka - Twarda

Data wydania

2011

strony

104

EAN

9783642154720

ISBN

3642154727

Enbook ID

01656549

Wydawca

Springer-Verlag Berlin and Heidelberg GmbH & Co. KG

Waga

770

Wymiary

155 x 235 x 17

Pełny opis

A copper-catalyzed direct synthesis of 2-(aminomethyl)indoles by catalytic domino reaction including multi-component coupling was developed, and is the first example of a three-component indole formation without producing salts as a byproduct. Based on this reaction, a copper-catalyzed synthesis of 3-(aminomethyl)isoquinoline was accomplished which represents an unprecedented isoquinoline synthesis through a four-component coupling reaction. Following these results, extensive application studies using one-pot palladium-, acid-, or base-promoted cyclization revealed that indole- or isoquinoline-fused polycyclic compounds can be readily synthesized through multi-component reactions. As the concept of Green Chemistry becomes ever more important, these findings may provide efficient and atom-economical approaches to the diversity-oriented synthesis of bioactive compounds containing a complex structure. This could lead to development of promising drug leads with structural complexity. The work of this thesis will go on to inspire the synthetic research of many readers.

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Copper-Catalyzed Multi-Component Reactions

Synthesis of Nitrogen-Containing Polycyclic Compounds

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