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Książka Cold Thermal Processing in the Spinal Cord Paul Wrigley

Cold Thermal Processing in the Spinal Cord

In Search of Therapeutic Targets for Cold Hyperesthesia

Autor: Paul Wrigley
Język: Angielski
Oprawa: Miękka
Wydawca: VDM Verlag Dr. Müller
Dostępność: Na zamówienie
Wysyłamy za 17-27 dni
286.66 zł
Two recently identified transient receptor potential (TRP) channels, TRPM8 and TRPA1, have been prop...

Informacje o książce

Autor
Paul Wrigley
Język
Angielski
Oprawa
Książka - Miękka
Data wydania
2010
strony
180
EAN
9783639103434
Enbook ID
06819328
Wydawca
VDM Verlag Dr. Müller
Waga
284
Wymiary
150 x 220 x 11

Pełny opis

Two recently identified transient receptor potential (TRP) channels, TRPM8 and TRPA1, have been proposed to play an important role in mammalian cool and cold peripheral sensory transduction. When expressed in cell-lines the cloned TRPM8 and TRPA1 receptors have distinct pharmacological and temperature response characteristics. Although these receptors are also transported to the central terminals of primary afferents, little is known about their centrally mediated actions. In this thesis an in vitro electrophysiological approach is used to investigate the dorsal horn processing of cool afferent modalities and the role of TRP ion channels. The results of this thesis provide further information on thermal processing, indicate direction for further research and suggest possible therapeutic targets for the management of abnormal cold sensory processing.

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