Cerebral Ischemia

Name: Cerebral Ischemia
Brand: Humana Press Inc.
SKU: 9780896035409
Price: 477.43 PLN
Availability: InStock

Molecular and Cellular Pathophysiology

Autor: Wolfgang Walz

Język:

Oprawa: Twarda

Wydawca: Humana Press Inc.

Dostępność: Dostępna u dostawcy w małych ilościach

Wysyłamy za 11-15 dni

477.43 zł

The human brain represents about 2% of the body weight, yet it accounts for approximately 20% of aer...

Informacje o książce

Autor

Wolfgang Walz

Język

Angielski

Oprawa

Książka - Twarda

Data wydania

1999

strony

278

EAN

9780896035409

ISBN

0896035409

Enbook ID

05251881

Wydawca

Humana Press Inc.

Waga

587

Wymiary

155 x 235 x 23

Pełny opis

The human brain represents about 2% of the body weight, yet it accounts for approximately 20% of aerobic metabolism. This high dependency on energy-consuming processes is mainly caused by the active transport of ions, which is necessary to compensate for the transmembrane ion currents that are part ofthe complex signaling processes in the brain. Ninety-five percent ofthe brain's ATP is derived from mitochondrial oxidative phosphorylation. Since that organ' s storage capacity for oxygen is minimal, any interruption of oxygen delivery to brain cells willlead to changes in membrane excitability and, there fore, to disruption of neuronal signaling within seconds. It seems that mamma lian brain is especially vulnerable to such an interruption, since oxygen deprivation leads to activation of ion channel mechanisms in neurons that impair their communications. Thus, the function of the brain as a coordinator of vital homeostatic reflexes, and complex body reactions to external challenges, depends critically on the rate of oxygen delivery and oxygen consumption. Oxygen delivery depends on two variables described in the Fick relation ship: volume flow rate ofblood and the arterial oxygen content. A reduction in either of these two variables will have serious effects on vital brain func tions. Reduction of arterial blood flow to the brain can be caused by cardiac arrest, shock, carotid occlusion, Of hypotension (global ischemia). Oxygen content is progressively decreased in asphyxia (including drowning).

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Cerebral Ischemia

Molecular and Cellular Pathophysiology

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