Książka Bootstrap methods for multi-factorial dose-response  designs Peter Frommolt

Bootstrap methods for multi-factorial dose-response designs

Methodology and applications

Język: Angielski
Oprawa: Miękka
Dostępność: Dostępna u dostawcy
Wysyłamy za 5-8 dni
197.76
Bifactorial designs are used to test for the efficacy§ of fixed combinations of two (or more) drugs....

Informacje o książce

Język
Angielski
Oprawa
Książka - Miękka
Data wydania
2009
strony
104
EAN
9783838109305
Enbook ID
06938532
Waga
173
Wymiary
150 x 220 x 7

Pełny opis

Bifactorial designs are used to test for the efficacy§ of fixed combinations of two (or more) drugs. Researchers are§ interested in the question if a combination has a§ significantly higher efficacy than either component drug§ alone. The power of the existing methods strongly depends on§ a nuisance parameter representing how much the respective§ means differ between the groups treated by the component§ drugs. Furthermore, the methods are only applicable under§ rather strict assumptions on the data. In this work, the§ distributions of the respective test statistics are§ approximated by bootstrap methods with data-based estimation§ of the marginal differences to overcome these limitations.§ This gives interesting insights about the role of unknown§ nuisance parameters in resampling procedures. The methods§ described are also expanded to related problems and more§ general questions and their power is evaluated by simulation§ studies. Finally, some examples for typical applications are§ worked out.

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