Bone Morphogenetic Proteins: Systems Biology Regulators

Autor: Slobodan Vukicevic, Kuber T. Sampath

Język:

Oprawa: Miękka

Wydawca: Springer International Publishing AG

Dostępność: Dostępna u dostawcy

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This book focuses on the salient features of the biology of Bone Morphogenetic Proteins and the adva...

Informacje o książce

Autor

Slobodan Vukicevic, Kuber T. Sampath

Język

Angielski

Oprawa

Książka - Miękka

Data wydania

2018

strony

445

EAN

9783319837536

Enbook ID

21374322

Wydawca

Springer International Publishing AG

Waga

940

Wymiary

155 x 235 x 24

Pełny opis

This book focuses on the salient features of the biology of Bone Morphogenetic Proteins and the advances in our understanding of their structure and function and of downstream signaling, as well as their governance in systems biology from bone and dentin to kidney, cancer, diabetes, iron homeostasis and angiogenesis, including rare musculoskeletal disorders. BMPs, also referred to as growth and differentiation factors, are members of the TGF-beta superfamily and are highly conserved from fruit flies to mammals and are responsible for the formation of practically every organ during embryo development and involved in adult tissue injury and repair. BMPs establish their extracellular gradient by interacting with their respective antagonists and regulate their function through SMAD-dependent down-stream signaling effector genes. This volume is aimed at scientists and professionals dealing with metabolic disorders, nutrition, systems biology diseases, rare musculoskeletal conditions, and disorders related to iron metabolism, including anemia of chronic disease, hereditary hemochromatosis and beta thalassemia.

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