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Książka Analyzing T Cell Responses D. Nagorsen

Analyzing T Cell Responses

How to analyze cellular immune responses against tumor associates antigens

Autor: D. Nagorsen, F. Marincola
Język: Angielski
Oprawa: Twarda
Wydawca: Springer-Verlag New York Inc.
Dostępność: Dostępna u dostawcy w małych ilościach
Wysyłamy za 13-18 dni
728.50 zł
This book reviews, describes, categorizes and provides a critical assessment of all assays that have...

Informacje o książce

Autor
D. Nagorsen, F. Marincola
Język
Angielski
Oprawa
Książka - Twarda
Data wydania
2005
strony
314
EAN
9781402036224
ISBN
1402036221
Enbook ID
01416238
Wydawca
Springer-Verlag New York Inc.
Waga
800
Wymiary
156 x 232 x 25

Pełny opis

This book reviews, describes, categorizes and provides a critical assessment of all assays that have been used for the monitoring of antigen-specific immune responses. In particular, it emphasizes a global approach to the analysis of T cell mediated target/host interactions at the systemic and the peripheral level when such interactions are supposed to occur. In addition, the tools described here could be utilized for the search of surrogate biomarkers predictive of treatment responsiveness and/or clinical outcome that are of interest to the biotechnology industry. In detail, this book provides an overview of antigen-specific immune biology in human models of tumor and viral disease, discusses modulation of such responses through immune escape and presents cellular assays (cytoxicity, proliferation, cytokine production using ELISPOT, intracellular staining or cytometric assessment, detection of antigen-specific T cells with tetrameric HLA/epitope complexes or MHC-IG dimers, T cell receptor analysis, assessment of T cell receptor/HLA interactions using peptide/HLA-Green Fluorescent Protein complexes incorporation) and molecular assays including quantitative real-time PCR and gene profiling for evaluation of systemic and peripheral immune responses.

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