Adenosine

Name: Adenosine
Brand: Springer-Verlag New York Inc.
SKU: 9781461439028
Price: 844.55 PLN
Availability: InStock

A Key Link between Metabolism and Brain Activity

Autor: Susan Masino, Detlev Boison

Język:

Oprawa: Twarda

Wydawca: Springer-Verlag New York Inc.

Dostępność: Dostępna u dostawcy

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This book assembles diverse recent research on regulating the influence of adenosine, outlines clini...

Informacje o książce

Autor

Susan Masino, Detlev Boison

Język

Angielski

Oprawa

Książka - Twarda

Data wydania

2012

strony

680

EAN

9781461439028

ISBN

1461439027

Enbook ID

01427883

Wydawca

Springer-Verlag New York Inc.

Waga

1202

Wymiary

155 x 235 x 41

Pełny opis

This book assembles diverse recent research on regulating the influence of adenosine, outlines clinical implications, and highlights emerging adenosine-based therapies. As examples, the relationship between adenosine and the highly altered metabolic state during hibernation has important predictions for neuroprotection. As part of a major paradigm shift, we now understand that the regulation of extracellular adenosine by astrocytes is critical for normal sleep and could be pivotal for the prevention and treatment of epilepsy. In addition, there is an established functional relationship where adenosine and dopamine receptors form receptor heteromers and extend the clinical reach of the regulation of adenosine directly into the realm of dopaminergic disorders and neuropsychiatry. Finally, a ketogenic (high-fat, low-carbohydrate) diet is a metabolic therapy used to treat pediatric and medically-refractory epilepsy for nearly 100 years. Although its efficacy is well established, the key neural mechanisms underlying its success remained unclear, hindering development of analogous pharmacological solutions. Converging evidence points to a critical link between ketogenic metabolism and increased adenosine.

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Adenosine

A Key Link between Metabolism and Brain Activity

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