Hot-melt extrusion (HME) - melting a substance and forcing itthrough an orifice under controlled conditions to form a newmaterial - is an emerging processing technology in thepharmaceutical industry f ...Cały opis
Hot-melt extrusion (HME) - melting a substance and forcing itthrough an orifice under controlled conditions to form a newmaterial - is an emerging processing technology in thepharmaceutical industry for the preparation of various dosage formsand drug delivery systems, for example granules and sustainedrelease tablets.
Hot-Melt Extrusion: Pharmaceutical Applications coversthe main instrumentation, operation principles and theoreticalbackground of HME. It then focuses on HME drug delivery systems, dosage forms and clinical studies (including pharmacokinetics andbioavailability) of HME products. Finally, the book includes somerecent and novel HME applications, scale -up considerations andregulatory issues. Topics covered include:
principles and die design of single screw extrusion
twin screw extrusion techniques and practices in the laboratoryand on production scale
HME developments for the pharmaceutical industry
solubility parameters for prediction of drug/polymermiscibility in HME formulations
the influence of plasticizers in HME
applications of polymethacrylate polymers in HME
HME of ethylcellulose, hypromellose, and polyethyleneoxide
bioadhesion properties of polymeric films produced by HME
taste masking using HME
clinical studies, bioavailability and pharmacokinetics of HMEproducts
injection moulding and HME processing for pharmaceuticalmaterials
laminar dispersive & distributive mixing with dissolutionand applications to HME
technological considerations related to scale-up of HMEprocesses
devices and implant systems by HME
an FDA perspective on HME product and processunderstanding
improved process understanding and control of an HME processwith near-infrared spectroscopy
Hot-Melt Extrusion: Pharmaceutical Applications is anessential multidisciplinary guide to the emerging pharmaceuticaluses of this processing technology for researchers in academia andindustry working in drug formulation and delivery, pharmaceuticalengineering and processing, and polymers and materials science.
This is the first book from our brand new series Advancesin Pharmaceutical Technology.Findout more about the series here.
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